Marika Charalambous studied Natural Sciences in Cambridge, and then completed a PhD at the University of Bath on the transcriptional control of the imprinted genes.
She was appointed to an Early Careers Fellowship at Queen Mary University of London in early 2013, and is now a Senior Lecturer in Endocrinology.
Her research career has focused primarily on the relationship between epigenetic gene dosage control and developmental physiology. Much of her work has utilised imprinted genes in the mouse as experimental models, since the epigenetic modulation of these exquisitely dosage-sensitive genes has important consequences for prenatal growth and development in mouse and man. Her work includes the demonstration that loss of imprinting on mouse chromosome 12 causes failure of timely development of brown adipose tissue, resulting in animals that are unable to survive the transition to independent postnatal life. She previously described a mouse model with defects in placental development and growth as a result of the loss of function of the imprinted Grb10 gene. In addition she undertook a training postdoctoral position in metabolic medicine in order to link her interest in prenatal growth and development with lifelong outcomes on metabolic health. Current work in Marika’s lab focuses on the roles of imprinted genes in the early life acquisition of adipose tissue and the development of the endocrine axes.